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Symbyax Drug Interactions

Intravenous Methylene Blue
Taking Symbyax with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Ketoconazole
Combining Symbyax with ketoconazole can raise the amount of Symbyax in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to adjust your doses of them to prevent this drug interaction from occurring.
 
Linezolid
Taking Symbyax with a linezolid can cause a group of symptoms called serotonin syndrome. These symptoms include:
 
  • Confusion
  • Hallucinations
  • A fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasms
  • Difficulty walking
  • Diarrhea.
 
Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.
 
Lithium
Symbyax may increase or decrease the level of lithium in your blood, perhaps making it less effective or increasing your risk of side effects. Also, taking Symbyax with lithium can cause serotonin syndrome. Talk to your healthcare provider before taking these medications together, and call him or her right away if you have any symptoms of serotonin syndrome, as it can be quite dangerous.
 
Medications That Prolong the QT Interval
Many different medications, including Symbyax, can cause a change in the heart rhythm known as QT prolongation, which can be very dangerous. Combining Symbyax with other QT-prolonging medications increases the risk of a life-threatening arrhythmia (torsade de pointes) caused by excessive QT prolongation. Check with your healthcare provider before combining such medications.
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Symbyax Drug Information

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