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Symbyax Drug Interactions

Symbyax and Serotonin Syndrome

Several of the known interactions with Symbyax are related to a potentially dangerous group of symptoms known as serotonin syndrome. Such symptoms might include:
 
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
 
Serotonin syndrome usually occurs when people take more than one medication that affects serotonin at the same time. Talk to your healthcare provider before taking these medications together. In many cases, such combinations are still recommended, although with more careful monitoring. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.
 

Symbyax Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Symbyax is combined with any of the drugs listed above.
 
Alcohol
People who are taking Symbyax are generally advised to avoid alcohol. Combining the two may cause unwanted side effects (see Alcohol and Symbyax).
 
Alprazolam
Taking Symbyax with alprazolam can increase the level of alprazolam in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to decrease your dose of alprazolam to prevent this from occurring.
 
Aspirin
If Symbyax and aspirin are taken together, it can increase your risk of stomach bleeding. Talk to your healthcare provider before combining the two.
 
Buspirone 
Because combining Symbyax with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
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Symbyax Drug Information

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