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Generic Symbyax

Four out of the five strengths of Symbyax (olanzapine and fluoxetine) are available in generic form. The FDA has determined that these generic medications are equivalent to brand-name Symbyax. However, the generic versions may have different inactive ingredients, which may cause problems for some people. At this time, Teva Pharmaceutical Industries is the only manufacturer of the generic versions.

An Overview of Generic Symbyax

Symbyax® (olanzapine and fluoxetine) is a prescription medication that is used to treat depression associated with bipolar disorder. It is also approved for treatment-resistant depression. It is a combination of two different medications: olanzapine (Zyprexa®) and fluoxetine (Prozac®).
Brand-name Symbyax is manufactured by Eli Lilly. However, it is also available in generic form, in some (but not all) strengths.

Availability of Generic Symbyax

Generic Symbyax is available in the following strengths:
  • Olanzapine/fluoxetine 6/25 mg capsules -- containing 6 mg olanzapine and 25 mg fluoxetine
  • Olanzapine/fluoxetine 6/50 mg capsules -- containing 6 mg olanzapine and 50 mg fluoxetine
  • Olanzapine/fluoxetine 12/25 mg capsules -- containing 12 mg olanzapine and 25 mg fluoxetine
  • Olanzapine/fluoxetine 12/50 mg capsules -- containing 12 mg olanzapine and 50 mg fluoxetine.
The Symbyax 3/25 mg strength is not yet available in generic form.
At this time, generic Symbyax is made by one manufacturer -- Teva Pharmaceutical Industries.

Is Generic Olanzapine/Fluoxetine as Good as Symbyax?

All generic medications must undergo certain tests to compare them to brand-name medications. The U.S. Food and Drug Administration (FDA) then looks at these tests to decide if the generics are equivalent to the brand-name medications and assigns a rating to each one.
An "AB" rating means that the FDA has determined that a generic medication is equivalent to a brand-name medication. The generic versions of Symbyax currently available have an "AB" rating, meaning they should be equivalent to Symbyax.
However, generic medications are allowed to have different inactive ingredients than the brand-name medication. This might include fillers, dyes, or other ingredients that may cause problems for people with allergies or sensitivities.
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