Seroquel Drug Interactions
When certain medications are taken with Seroquel, drug interactions may occur. Medicines that may have negative interactions include certain antibiotics or antifungals, lorazepam, and thioridazine. Seroquel drug interactions can decrease the effectiveness of both medications, increase the drug levels in your blood, or cause the drugs to lose their effectiveness, so your healthcare provider may adjust your dosages as necessary.
Seroquel® (quetiapine fumarate) can potentially interact with a number of other medicines. Some of the medicines that may lead to Seroquel drug interactions include:
- Certain antibiotics or antifungals, including:
- Cimetidine (Tagamet®)
- Divalproex (Depakote®, Depakote ER®)
- Lorazepam (Ativan®)
- Medications that cause a certain change in heart rhythm (see QT-Prolonging Medications for a list)
- Phenytoin (Dilantin®, Phenytek®)
- Thioridazine (Mellaril®).
The following sections explain in detail the potentially negative interactions that can occur when Seroquel is combined with any of the drugs listed above.