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In previous clinical studies of olanzapine for schizophrenia, people taking the medication experienced improvements in their schizophrenia symptoms (including hallucinations and suspiciousness), compared to those not taking it. Longer studies also showed that olanzapine can help people from needing to be hospitalized and can help symptoms from returning.
Clinical studies have also shown olanzapine to be effective for bipolar disorder treatment. In these studies, the drug was effective when used alone or with other bipolar disorder medications.

When and How to Take Olanzapine

Following are some general considerations for when and how to take the medication:
  • Olanzapine comes in tablet form. It is usually taken by mouth once a day.
  • You can take it with or without food. If the medication bothers your stomach, try taking it with food.
  • Olanzapine is also available in tablets that are meant to dissolve rapidly in the mouth. These tablets are called Zyprexa Zydis® tablets. They do not need to be taken with water.


  • A long-acting injection form (known as Zyprexa Relprevv™) is available and is given just once every two or four weeks. A short-acting injection form is also available. 


  • Oral forms of this medication should be taken at the same time each day to maintain even levels of the drug in your blood.
  • For the medication to work properly, it must be taken as prescribed. It will not work if you stop taking it.


The dosage your healthcare provider recommends will vary depending on a number of factors, including:
  • The medical condition being treated
  • Your age
  • The severity of your condition
  • Other medical conditions you may have
  • Other medications you may be currently taking.
As is the case with any medication, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
(Click Olanzapine Dosing for more information.)
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Olanzapine (Zyprexa)

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