Bipolar Disorder Home > Adasuve

Adasuve is a medicine prescribed to treat acute agitation in people with schizophrenia or bipolar disorder. It comes as a powder that is inhaled by mouth. The medication is taken only when you need it. Some possible side effects of the drug include sedation, a sore throat, and a bad taste in your mouth.

What Is Adasuve?

Adasuve™ (loxapine inhalation powder) is a prescription medication approved to treat acute agitation in people with schizophrenia or bipolar disorder. It belongs to a group of medicines known as typical antipsychotics. Adasuve is unique because it is inhaled through the mouth. Other medicines approved to treat acute agitation are given as injections.
 
(Click Adasuve Uses for more information, including possible off-label uses.)
 

Who Makes This Medication?

Adasuve is made by Alexza Pharmaceuticals, Inc.
 

Clinical Effects

In clinical studies, Adasuve was shown to quickly reduce agitation in people with schizophrenia or bipolar I disorder. In these studies, people with these disorders who were experiencing agitation were given either Adasuve or a placebo inhaler (an inhaler with no active ingredient). After two hours, those given Adasuve were significantly less agitated than those given the placebo. The effects of Adasuve were apparent as soon as 10 minutes after the dose was given.
 

How Does Adasuve Work?

Adasuve belongs to a group of medicines known as typical antipsychotics. The drug is known to block the effects of dopamine, an important chemical in the brain that is believed to be elevated in people with schizophrenia. It also blocks the effects of another brain chemical known as serotonin, but to a lesser degree. However, it is not entirely known how these actions help treat agitation.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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