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Lithium Drug Interactions

Lithium Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when lithium is combined with any of the drugs listed above.
 
Angiotensin-Converting Enzyme Inhibitors
ACE inhibitors may increase the level of lithium in your blood, potentially increasing your risk of lithium side effects and lithium toxicity. Talk to your healthcare provider before taking these medications together.
 
Angiotensin II Receptor Blockers
ARBs may increase the level of lithium in your blood, possibly increasing your risk of side effects and lithium toxicity. Talk to your healthcare provider before taking these medications together.
 
Antipsychotic Medications
There have been reports of problems when lithium is combined with antipsychotic medications. These problems include minor side effects, as well as serious brain damage. Some of these antipsychotic medications can be used to treat bipolar disorder, but be sure to talk with your healthcare provider before taking them with lithium, as you may need to be monitored more closely.
 
Diuretics
Diuretics can interact with lithium in several different ways. Some may increase the risk of side effects and toxicity, while others can make lithium less effective. Check with your healthcare provider before combining lithium with any diuretic.
 
Nonsteroidal Anti-Inflammatory Drugs
NSAIDs can increase the level of lithium in your blood, possibly increasing your risk of side effects and toxicity. If you are taking lithium, talk with your healthcare provider before starting, increasing, or stopping an NSAID (including non-prescription NSAIDs). You may need to have the level of lithium in your blood checked, and your healthcare provider may need to adjust your lithium dose.
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