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When and How to Take Lamotrigine

General considerations for when and how to take the medication include the following:
  • Lamotrigine comes in regular tablets, orally disintegrating tablets, and lamotrigine CD tablets. It is taken by mouth, usually once or twice a day.
  • Lamotrigine CD tablets are "chewable dispersible" tablets. These tablets can be swallowed whole, chewed, or "dispersed" in a small amount of liquid. To disperse the CD tablets, add the tablet to a small amount of liquid, about a teaspoonful or enough to cover the tablet. Wait a minute, then swirl the liquid to make sure the tablet is broken down, and take by mouth immediately.

Do not attempt to take a partial dose of lamotrigine CD tablets by cutting them in half or taking half of the dispersed tablet in liquid. 

  • Regular lamotrigine tablets can be broken in half if necessary to obtain the proper dosage. However, these tablets can be particularly difficult to break. You may want to consider purchasing a "pill splitter" or ask your pharmacist to split them for you.


  • The orally disintegrating tablets should be placed on the tongue and moved around in the mouth. They will dissolve rapidly. They can be swallowed with or without water.


  • The medication can be taken with or without food. If it upsets your stomach, try taking it with food.
  • It should be taken at the same time(s) each day to maintain an even level in your blood.
  • For the medication to work properly, it must be taken as prescribed. It will not work if you stop taking it.
  • Do not stop taking lamotrigine without first discussing it with your healthcare provider (see Lamictal Withdrawal).
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