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Drug Interactions With Lamotrigine

Divalproex or Valproic Acid
Divalproex or valproic acid can increase the level of lamotrigine in your blood, possibly increasing your risk of side effects. Taking these medications together can increase your risk of a life-threatening skin rash (see Lamictal Rash). Your healthcare provider will likely recommend a lower lamotrigine dosage if you are taking divalproex or valproic acid.
 
Oral Contraceptives or Hormone Replacement Therapy
Oral contraceptives (birth control pills) or hormone replacement therapy (HRT) can decrease the level of lamotrigine in your blood, making it less effective. This is especially problematic for cyclical birth control pills or hormone replacement therapies that have a week of inactive pills to allow you to have your period, as your lamotrigine levels will increase during the inactive pill week.
 
Talk to your healthcare provider about other birth control options; a non-hormonal method (such as condoms) may be best for your situation.
 
Phenobarbital
Phenobarbital can decrease the level of lamotrigine in your blood, possibly making it less effective. Your healthcare provider may recommend a higher lamotrigine dose if you are taking phenobarbital and may recommend decreasing the dose if you stop taking phenobarbital.
 
Phenytoin
Phenytoin may decrease the level of lamotrigine in your blood, perhaps making it less effective. Your healthcare provider may recommend a higher dose of lamotrigine if you are taking phenytoin and may recommend decreasing the dose if you stop taking phenytoin.
 
Primidone
Primidone may decrease the level of lamotrigine in your blood, possibly making it less effective. Your healthcare provider may recommend a higher lamotrigine dose if you are taking primidone and may recommend decreasing the dose if you stop taking primidone.
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