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In one study, the drug was added on to other seizure medications in people with complex partial seizures that were not adequately controlled. Those who added Depakote to their seizure medications decreased their seizure frequency, compared to those who did not take the drug.
Other studies have shown that using it alone is also effective for complex partial seizures.

When and How to Take Depakote

Some general considerations for when and how to take the medication include:
  • The drug comes in the form of delayed-release tablets and "sprinkle capsules."
  • It can be taken with or without food. If the medicine upsets your stomach, try taking it with food.
  • Do not crush, break, or chew the tablets, as this will destroy the protective coating.
  • Depakote Sprinkle capsules can be swallowed whole or can be opened and the contents sprinkled on a spoonful of soft food (such as pudding or applesauce). Do not chew the contents, as each tiny bead is delayed-release, with a special protective coating.
  • The medication should be taken at the same times each day to maintain even levels of the drug in your blood.
  • For the medication to work properly, it must be taken as prescribed. It will not work if you stop taking it.
  • Do not stop taking the medication without first discussing it with your healthcare provider (see Depakote Withdrawal).

Dosing Information

The dosage that your healthcare provider recommends will vary depending on a number of factors, including:
  • The medical condition being treated
  • Your weight
  • Other medications you may be taking
  • Other medical conditions you may have.
As always, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
(Click Depakote Dosage for more information.)
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Depakote Medication Information

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