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Depakote for Migraines

The prescription medicine Depakote® (divalproex sodium) is used for the treatment of epileptic seizures and mania associated with bipolar disorder. Many healthcare providers will also recommend Depakote for migraines.
Migraine headaches are different from other headaches in many ways. Some of the most common migraine symptoms include:
  • Headache pain on one side of the head
  • Sensitivity to light or sound
  • Throbbing headache pain
  • Upset stomach (nausea) and vomiting
  • Unusual vision changes.
Some people may have an aura before their migraines occur. An aura can be any unusual sign that a migraine is about to happen, including vision changes, numbness, tingling, or speech changes. Some people have migraine triggers, which are certain foods, drinks, or situations that seem to lead to a migraine (see Migraine Diet for more information).
Due to the way it works, this medicine will not help for migraine treatment. Depakote is taken on a daily basis for migraine prevention, to reduce the frequency or severity of migraine headaches.
(Click Depakote Uses for information on how this drug works for migraines, for more details on what else the medication is used for, and to find out whether it is approved for use in children.)
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