When medicines like phenytoin or rifampin are taken together with Depakote, drug interactions may potentially occur. Among other things, these interactions may affect the level of Depakote in your blood -- which can increase your risk of developing side effects -- or decrease the effectiveness of the drug. A few other drugs that may cause Depakote interactions include carbamazepine, primidone, lamotrigine, and warfarin.
Depakote® (divalproex sodium) can potentially interact with many other medications. Some of these medicines that may lead to Depakote interactions include: