Depakote 500 mg Tablets

Depakote® (divalproex sodium) is approved for treating and preventing several different conditions. The capsule form of this drug comes in only one strength; there are three strengths available for the tablet form of Depakote: 500 mg tablets, 250 mg tablets, and 125 mg tablets.
 
Manic Depression
The recommended starting dosage for treating mania associated with bipolar disorder is 750 mg total per day (divided into two or more smaller doses per day).
 
Migraines
For migraine prevention, the recommended starting dose is 250 mg twice daily. If needed, your healthcare provider may recommend that you take 500 mg Depakote tablets (one tablet, twice daily).
 
Epilepsy
The recommended starting Depakote dose for complex partial seizures is based on your weight -- 10 mg to 15 mg per kg of body weight total per day. For complex or partial absence seizures, the starting dose is 15 mg per kg of body weight total per day. For either type of seizure, if the total daily dose is more than 250 mg, it should be split up into two or three smaller doses per day.
 
(Click Depakote Dosage for more information on how dosing works for Depakote, to find out what your healthcare provider will consider before making a dosing recommendation for your situation, and for tips on using this particular medication.)
 
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