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Depakote 250 mg Tablets

The dose of Depakote® (divalproex sodium) that your healthcare provider recommends will vary, depending on the condition being treated, your weight, and various other factors.
The usual starting dosage for treating mania is 750 mg total per day (divided into two or more smaller doses per day). Your healthcare provider will probably increase your dose rapidly in order to control your bipolar disorder symptoms.
The recommended starting Depakote dose for complex partial seizures is based on your weight -- about 4.5 mg to 6.8 mg per pound of body weight total per day. For complex or partial absence seizures, the starting dose is about 6.8 mg per pound of body weight total per day. For either type of seizures, if the total daily dose is more than 250 mg, it should be split up into two or three smaller doses per day.
Most people taking this drug for migraine prevention start with 250 mg Depakote tablets (one tablet, twice daily). If needed, your healthcare provider can increase your dose up to 500 mg twice daily.
(Click Depakote Dosage for more detailed dosing information for this drug and for general suggestions on when and how to take Depakote.)
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