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Side Effects of Asenapine

While most people have no problems with asenapine, side effects are possible. Common ones include constipation, vomiting, and weight gain. If such reactions occur, they are generally mild and easily treated. However, potentially serious side effects, such as heart palpitations or abnormal menstrual periods, should be reported to your healthcare provider for diagnosis and treatment.

An Introduction to Asenapine Side Effects

As with any medicine, side effects are possible with asenapine (Saphris®). However, not everyone who takes the drug will experience problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with asenapine. Your healthcare provider can discuss a more complete list with you.)

Serious Side Effects of Asenapine

Some of asenapine's side effects are potentially serious -- even life-threatening -- and should be reported to your healthcare provider. These include, but are not limited to:
  • An irregular heart rhythm (arrhythmia)
  • Dizziness, lightheadedness, or fainting, which may be signs of low blood pressure or an arrhythmia
  • Heart palpitations
  • Large or rapid weight gain (see Saphris and Weight Gain)
  • Extrapyramidal symptoms, such as:
    • Feelings of internal restless or jitteriness
    • Unusual, uncontrollable body movements
    • Strong, uncontrollable muscle contractions
  • Signs of hormonal imbalance, such as:
  • Frequent or persistent infections, which may be a sign of low white blood cells
  • Heat stroke
  • Difficulty swallowing
  • Signs or symptoms of neuroleptic malignant syndrome (NMS), which can include:
    • A high fever
    • Stiff muscles
    • Confusion
    • Irregular pulse or blood pressure
    • An increased heart rate (tachycardia)
    • Sweating
    • Irregular heart rhythms (arrhythmias)
  • Signs of an allergic reaction, including:
    • Unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Wheezing
  • Difficulty breathing or swallowing.
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Asenapine Drug Information

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