Drug Interactions With Asenapine
Alcohol or Medications That Cause Drowsiness
Combining asenapine with alcohol or medications that cause drowsiness could cause undesirable or even potentially dangerous side effects, such as extreme drowsiness, "passing out," confusion, or impaired breathing.
Blood Pressure Medications
Taking asenapine with a high blood pressure medication might increase the risk of low blood pressure (hypotension). Be sure to watch for signs of this problem, such as lightheadedness, dizziness, or fainting.
Asenapine is metabolized by a specific liver enzyme known as CYP1A2. Some other medications, known as CYP1A2 inhibitors, slow down the activity of this enzyme, causing an increase in the level of asenapine in the blood. This could lead to serious side effects of asenapine. Check with your healthcare provider before combining these two medications.
In general, asenapine should not be combined with any other medications that can cause QT prolongation (a certain change in the heart rhythm), due to the risk of a life-threatening arrhythmia.
Final Thoughts on Asenapine Drug InteractionsIt is possible that not all drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions with asenapine that may apply to you.