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Clinical Effects of Asenapine

In two of three clinical studies for the treatment of schizophrenia, people taking asenapine experienced an improvement in their schizophrenia symptoms, compared to those taking a placebo (a "sugar pill" with no active ingredients). However, in one clinical study, asenapine was no better than the placebo.
Clinical studies have also shown asenapine to be effective for bipolar disorder treatment. In these studies, the medication was effective for treating either episodes of mania or mixed episodes, which involve both mania and depression.

When and How to Take It

Some general considerations to keep in mind when taking asenapine include the following:
  • Asenapine comes in the form of a sublingual tablet (a special type of tablet that dissolves under the tongue). It is usually taken by mouth twice a day.
  • Do not crush or chew the tablets or swallow them whole. They will rapidly dissolve under the tongue. Do not eat or drink for 10 minutes after taking a dose.
  • Try to take this medication at the same times each day.
  • Asenapine tablets come in special blister packaging designed to protect the delicate tablets. Be sure to peel back the packaging as directed; do not try to push the tablets through the packaging, as this will crush them. Keep each tablet in the original packaging until just before use.
  • For this medicine to work properly, it must be taken as prescribed. Asenapine will not work if you stop taking it.

Dosing Information

The dose of asenapine your healthcare provider recommends will vary, depending on a number of factors, including:
  • The medical condition being treated (schizophrenia or bipolar disorder)
  • How you respond to asenapine
  • Other medications you may be taking
  • Other medical conditions you may have.
As always, do not adjust your dose unless your healthcare provider specifically tells you to do so.
(Click Asenapine Dosage for more information.)
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Asenapine Drug Information

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