What Should I Tell My Healthcare Provider?Prior to taking asenapine, talk to your healthcare provider if you have:
- A narrowing of the gastrointestinal tract (such as a stricture)
- Kidney disease, including kidney failure (renal failure)
- Alzheimer's disease or other forms of dementia
- Low blood pressure (orthostatic hypotension)
- An irregular heart rhythm (arrhythmia)
- An electrolyte imbalance
- A slow heart rate (bradycardia)
- Heart disease, congestive heart failure (CHF), or other heart problems
- Any allergies, including to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see Saphris and Pregnancy)
- Breastfeeding (see Saphris and Breastfeeding).
Make sure to tell your healthcare provider about all of the medications you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Asenapine to learn more, including information on who should not take the drug.)
How Does Asenapine Work?Asenapine belongs to a group of medications called atypical (or second-generation) antipsychotic medications. It is not entirely clear how asenapine works for the treatment of schizophrenia and bipolar disorder. However, it is known that the drug blocks or lessens the effects of certain chemicals in the brain. These chemicals, such as dopamine and serotonin, may be elevated in people with schizophrenia or bipolar disorder.