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Asenapine Dosage

When used for the treatment of schizophrenia, the usual dose of asenapine is 5 mg, twice a day. The amount is slightly higher when used to treat bipolar disorder. The quickly dissolving tablets are placed under the tongue; they are not chewed or crushed. To ensure an effective treatment process, it is best to take each dosage at the same time each day.

An Introduction to Dosing With Asenapine

The dosage of asenapine (Saphris®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The medical condition being treated (schizophrenia or bipolar disorder)
  • How you respond to asenapine
  • Other medications you may be taking
  • Other medical conditions you may have.
As is always the case, do not adjust this amount unless your healthcare provider specifically tells you to do so.

Asenapine Dosage for Schizophrenia

The recommended dose of asenapine for the treatment of schizophrenia is 5 mg twice daily. If necessary, your healthcare provider may increase your dosage up to 10 mg twice daily, although this may increase the risk of side effects.

Asenapine Dosage for Bipolar Disorder

The recommended dosage for the acute treatment of manic or mixed episodes of bipolar disorder is 10 mg twice daily. If necessary, your healthcare provider may decrease the amount to 5 mg twice daily if bothersome side effects occur.
For people combining asenapine with lithium or valproate medications (such as Depakene®, Depakote®, or Depakote ER®), the starting dosage is asenapine 5 mg twice daily. If necessary, your healthcare provider may increase the dosage up to 10 mg twice daily.
As with schizophrenia, asenapine is not approved for long-term bipolar disorder treatment; however, your healthcare provider will likely recommend that you stay on this medication as long as significant benefit is seen.
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